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Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Dec 25, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

Macular imaging with optical coherence tomography in glaucoma.

Vahid Mohammadzadeh¹, Nima Fatehi², Adeleh Yarmohammadi³

¹Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.

Survey of Ophthalmology

|March 23, 2020

Summary

Spectral-domain optical coherence tomography (SD-OCT) of the macula is a powerful tool for detecting early glaucoma. This imaging technique offers high reproducibility and is increasingly vital for monitoring glaucoma progression.

Keywords:

OCT detection glaucoma imaging macula optical coherence tomography progression structure-function variability

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Area of Science:

Ophthalmology
Medical Imaging
Glaucoma Research

Background:

Spectral-domain optical coherence tomography (SD-OCT) enables rapid imaging of posterior eye segments.
Key anatomical areas include the optic nerve head, circumpapillary retinal nerve fiber layer, and macula.

Purpose of the Study:

To review the role of macular SD-OCT in glaucoma diagnosis and management.
To highlight emerging diagnostic applications of macular SD-OCT in ophthalmology.

Main Methods:

Comprehensive literature review focusing on macular SD-OCT in glaucoma.
Analysis of evidence supporting SD-OCT for early glaucoma detection and progression monitoring.

Main Results:

Ample evidence supports macular SD-OCT for early glaucoma detection.
Macular SD-OCT measurements show high reproducibility.
Accumulating evidence demonstrates utility in tracking glaucoma progression.

Conclusions:

Macular SD-OCT is an essential diagnostic tool in modern glaucoma care.
Its application extends from early detection to monitoring disease advancement.