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Behavioral Effects of Neuronal, Parent-specific Commd1 Knockout in Mice
Kayla A Chase1, Jazlene E Mallari2, Yvette Tan2
1University of California, Department of Psychiatry, 9500 Gilman Drive, La Jolla, CA 92093, United States; University of Illinois at Chicago, Department of Psychiatry, 900 S. Ashland Ave, Chicago, IL 60612, United States.
Neuroscience
|March 23, 2020
Summary
This study reveals Commd1 gene
Area of Science:
- Neuroscience
- Genetics
- Behavioral Science
Background:
- Commd1 is an imprinted gene, preferentially maternally expressed, located in a critical genomic region influencing sensorimotor gating.
- Previous research linked this genomic region to sensorimotor gating deficits, but the specific role of Commd1 remained unclear.
Purpose of the Study:
- To investigate the in vivo behavioral consequences of brain-specific Commd1 knockout.
- To determine the influence of the parent of origin on Commd1's function and associated behaviors.
Main Methods:
- Generation of conditional Commd1 mutant mice bred with Syn1-Cre driver lines.
- Analysis of Commd1 mRNA levels in offspring with maternally or paternally derived knockouts.
- Phenotypic assessment using open field, sensorimotor gating, and forced swim tests.
Main Results:
- Measurable Commd1 knockout was observed exclusively in the maternally derived line.
- Maternal Commd1 knockout mice exhibited altered stereotypy and depressive-like behaviors.
- Specific behavioral changes included decreased swimming and increased immobility in the forced swim test for maternal knockout mice.
Conclusions:
- This study provides the first in vivo evidence for a behavioral role of Commd1.
- Parent-of-origin effects are critical for Commd1's behavioral influence.
- Highlights the importance of considering parental origin in Cre-based knockout studies.
