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Published on: October 24, 2012
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Central auditory processing in adults with chronic stroke without hearing loss: A magnetoencephalography study
Takako Fujioka1, Claudia Freigang2, Kie Honjo3
1Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada; Department of Music, Stanford University, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, CA, USA.
Summary
Stroke can disrupt central auditory processing even with normal hearing. Auditory evoked responses (AERs) reveal these deficits, suggesting rehabilitation for stroke survivors.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Stroke Research
Background:
- Stroke lesions outside auditory cortex can impair higher-order central auditory processing.
- Stroke survivors with unilateral arm/hand impairment may experience subtle auditory deficits.
- Auditory evoked responses (AERs) offer a method to assess central auditory function.
Purpose of the Study:
- To characterize auditory functions in chronic stroke survivors with unilateral arm/hand impairment.
- To investigate the relationship between AERs, lesion location, and behavioral auditory performance.
- To explore the neural mechanisms underlying higher-order auditory perception after stroke.
Main Methods:
- Recorded AERs in 29 stroke survivors and 14 controls using various auditory stimuli (tones, oddballs).
- Assessed behavioral performance in speech-in-noise, mistuning, and sound-motion detection.
- Examined correlations between AERs, behavior, and lesion overlap with functional networks.
Main Results:
- Eight patients showed unilateral AERs with reduced amplitude, unlike controls with bilateral AERs.
- Lesions in basal ganglia/white matter delayed N1/P2 waves; attention network lesions affected MMN and P3a responses.
- Impaired speech-in-noise perception was linked to AER measures and frequency-deviant detection.
Conclusions:
- AERs demonstrate disrupted auditory functions from non-temporal lobe stroke damage.
- These findings highlight the complexity of neural mechanisms in higher-order auditory perception.
- Stroke survivors may benefit from auditory processing rehabilitation, even without overt hearing loss.
