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Updated: Dec 25, 2025

Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids
Published on: January 26, 2012
Computational approaches to unravel the pathways and evolution of specialized metabolism
1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.
Abstract:
Specialized metabolites serve as a chemical arsenal that protects plants from abiotic stress, pathogens, and herbivores, and they are an essential component of our nutrition and medicine. Despite their importance, we are still at the beginning of unravelling biosynthetic pathways that produce these compounds, which is needed to produce more resilient and nutritious crops, expand our inventory of useful biomolecules, and give valuable insights into plant evolution. This review focuses on the evolution of specialized metabolism in the plant kingdom and the state-of-the-art approaches used to identify the biosynthetic pathways of these useful compounds.
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