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Related Experiment Video

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A study on bone tissue engineering: Injectable chitosan-g-stearic acid putty.

Volkan Yalman1, Ekin Çelik2, Ömer Arslan3

  • 1Department of Molecular Biology and Genetics, Yıldız Technical University, Istanbul, 34349, Turkey.

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
|March 23, 2020
PubMed
Summary

Chitosan grafted stearic acid (Ch-g-Sa) and nano-hydroxyapatite (HA) putties show promise for bone regeneration. These biomaterials demonstrated good biocompatibility and osteogenic potential in cell studies.

Keywords:
Bone graftchitosan-g-stearic acid puttycytokine levelsinjectable puttyoxidant properties

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Bioengineering products offer potential for enhancing bone tissue regeneration.
  • Developing effective biomaterials is crucial for advancing bone regeneration therapies.

Purpose of the Study:

  • To synthesize and evaluate a novel chitosan (Ch) grafted stearic acid (Ch-g-Sa) polymer as a putty for bone regeneration.
  • To assess the physical, chemical, and biological properties of Ch-g-Sa/nano-hydroxyapatite (HA) composite putties.

Main Methods:

  • Ch-g-Sa polymer characterized by Proton nuclear magnetic resonance (H-NMR) and Fourier-transformed infrared spectroscopy-attenuated total reflectance (FTIR-ATR).
  • Thermal properties analyzed using thermal gravimetric analysis (TGA).
  • In-vitro degradation, viscosity, cytotoxicity, osteogenic potential (ALP and RUNX2 gene expression), and inflammatory effects were evaluated using MC3T3 and THP-1 cell lines.

Main Results:

  • Ch-g-Sa/HA putties exhibited favorable in-vitro degradation and viscosity properties.
  • The putties showed no significant cytotoxicity and did not induce oxidation.
  • Demonstrated significant osteogenic potential and a low inflammatory effect in cellular assays.

Conclusions:

  • Chitosan grafted stearic acid/nano-hydroxyapatite (Ch-g-Sa/HA) composite putties are promising biomaterials for bone tissue regeneration.
  • The synthesized polymer and its composite form exhibit suitable characteristics for bone void filling applications.