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Updated: Dec 25, 2025
07:15
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
10.1K
Probiotic-directed modulation of gut microbiota is basal microbiome dependent
Qiangchuan Hou1, Feiyan Zhao1, Wenjun Liu1
1Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Key Laboratory of Dairy Products Processing, Ministry of Agriculture, Inner Mongolia Agricultural University , Huhhot, China.
Gut Microbes
|March 24, 2020
Summary
Probiotic Lactobacillus casei Zhang (LCZ) consumption impacts gut microbiota composition differently based on individual
Area of Science:
- Microbiology
- Human Gut Microbiome Research
- Probiotics
Background:
- Growing demand for probiotics to improve health.
- Uncertainty regarding regional variations in probiotic efficacy.
- Need to understand probiotic strain effects on diverse populations.
Purpose of the Study:
- To investigate the impact of Lactobacillus casei Zhang (LCZ) on gut microbiota in healthy adults from different Asian regions.
- To analyze individual variations in response to LCZ consumption.
- To propose a metric for quantifying probiotic effects on gut microecology.
Main Methods:
- PacBio SMRT sequencing for gut microbiota analysis.
- Collection of samples before, during, and after LCZ consumption.
- Development of a Gut Microbiota Variability Index (GMVI).
Main Results:
- LCZ consumption effects are linked to baseline gut microbiota composition.
- Significant regional differences in GMVI observed (Xinjiang highest, Singapore lowest).
- LCZ increased beneficial bacteria (Lactobacillus, Roseburia) and decreased harmful bacteria (Blautia).
- LCZ promoted enterotype shifts and increased lactic acid bacteria.
- LCZ modulated metabolic pathways, enhancing amino acid biosynthesis and phosphate metabolism while reducing lipopolysaccharide synthesis.
Conclusions:
- Individual gut microbiota composition significantly influences LCZ probiotic efficacy.
- LCZ consumption demonstrates potential health benefits through modulation of gut bacteria and metabolic functions.
- The GMVI offers a quantitative approach to assess probiotic impact on gut microecology.
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