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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Not all HLA epitope mismatches are equal

Sebastiaan Heidt1, Frans H J Claas1

  • 1Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands.

Kidney International
|March 24, 2020
PubMed

The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.

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