ROS and oncogenesis with special reference to EMT and stemness
Ritam Chatterjee1, Jyotirmoy Chatterjee1
1School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
European Journal of Cell Biology
|March 24, 2020
Summary
Reactive oxygen species (ROS) play a dual role in cancer, influencing normal cell functions and causing oxidative stress. This review explores ROS
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Reactive oxygen species (ROS) are crucial for cellular signaling in redox biology.
- Elevated ROS levels cause oxidative stress, damaging cellular components and contributing to diseases like cancer.
- ROS act as a "double-edged sword" in oncogenesis, potentially suppressing or promoting tumor progression.
Purpose of the Study:
- To review the multifaceted roles of ROS in tumor biology.
- To highlight the involvement of ROS in epithelial-mesenchymal transition (EMT) and cancer stem cells.
Main Methods:
- Literature review of studies on ROS, oxidative stress, and cancer.
- Analysis of signaling pathways influenced by ROS in neoplasia.
Main Results:
- ROS can promote or suppress cancer progression depending on the signaling pathways involved.
- ROS contribute to phenotypic plasticity and the acquisition of stemness in cancer cells.
- The review synthesizes current understanding of ROS in EMT and cancer stem cell biology.
Conclusions:
- ROS are critical regulators in cancer development and progression.
- Targeting ROS pathways may offer therapeutic strategies for cancer treatment.
- Further research into ROS, EMT, and cancer stem cells is warranted.
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