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Attributable risk of all-cause mortality in hypertensive adults based on disease risk prediction model: A Chinese

Weiwei Sun1, Yanhong Huo2, Qingqing Liu3

  • 1Department of Nephrology, Dongzhimen Hospital, Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.

Journal of Infection and Public Health
|March 24, 2020
PubMed

Insights

Hypertension increases mortality risk, particularly in older males with low education, smoking habits, and reduced kidney function. Early interventions like smoking cessation and renal protection are crucial for hypertensive patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Hypertension is a significant global health concern.
  • Estimating mortality risk in hypertensive populations is crucial for public health strategies.

Purpose of the Study:

  • To determine the attributable risk for all-cause mortality in hypertensive adults in Beijing, China.
  • To identify key prognostic factors for mortality in this cohort.

Main Methods:

  • Prospective cohort study of 3006 hypertensive patients aged 50+ in Beijing.
  • Data collected included demographics, lifestyle factors, comorbidities, and blood pressure.
  • Follow-up for mortality risk assessment over approximately 4.9 years.

Main Results:

  • Significant survival differences observed based on gender, renal function, smoking status, hypertension severity, education, and coronary heart disease.
  • Independent risk factors for mortality included male gender, low education (<6 years), age ≥65, smoking, and severely decreased estimated glomerular filtration rate (eGFR <60 mL/min/1.73m²).

Conclusions:

  • Decreased eGFR, advanced age, smoking, low education, and male gender are independent risk factors for mortality in hypertensive individuals.
  • Recommendations include protecting renal function, patient education, and smoking cessation.
  • Early detection of kidney impairment and smoking cessation are vital for hypertensive patients.
Abstract

Keywords:
Attributable riskHypertensionRenal functionRisk prediction model

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