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Related Experiment Video

Updated: Dec 25, 2025

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
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Long-Term Outcomes After Linac Radiosurgery for Benign Meningiomas.

P Pou1, J Biau1, P Verrelle2

  • 1Department of Radiation Oncology, Jean Perrin Center, Clermont-Ferrand, France.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|March 24, 2020
PubMed
Summary

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Assessment of morbidity and mortality in emergency tracheotomy in head-and-neck cancer patients under palliative care.

European annals of otorhinolaryngology, head and neck diseases·2026
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International guidelines for the delineation of the postoperative clinical target volumes (CTV) for parotid and submandibular gland cancers.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
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Local relapse patterns after preoperative radiotherapy of limb and trunk wall soft tissue sarcomas: Prognostic role of imaging and pathologic response factors.

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Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024

Linac-based stereotactic radiosurgery (SRS) for benign meningiomas demonstrates excellent long-term local control and safety. Ensuring a minimum tumor dose above 10 Gy is crucial for better progression-free survival (PFS).

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Benign meningiomas are common primary brain tumors.
  • Stereotactic radiosurgery (SRS) is a treatment option, but Linac-based SRS outcomes require further evaluation.
  • Limited data exists on long-term efficacy of Linac-based SRS for these tumors.

Purpose of the Study:

  • To evaluate the long-term outcomes of Linac-based SRS for benign intracranial meningiomas.
  • To identify prognostic factors influencing local control, progression-free survival (PFS), and overall survival.

Main Methods:

  • Retrospective single-center study of 60 patients with 69 benign meningiomas treated between July 1996 and May 2011.
  • Single-fraction Linac-based SRS with 4-5 non-coplanar arcs, prescribed peripheral dose of 16 Gy.
Keywords:
Efficacylinacmeningiomasradiosurgerytoxicity

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  • Analysis of prognostic factors for local control, PFS, and overall survival.

    • Main Results:

    • Median follow-up of 128 months with no loss to follow-up.
    • 10-year local control: 92.6%, PFS: 78%, overall survival: 92.7%.
    • Higher local control for skull base/parasagittal meningiomas (P=0.031); longer PFS with minimum tumor dose >10 Gy (P=0.0082). No Grade 5 toxicity.

    Conclusions:

    • Linac-based SRS offers excellent long-term local control and safety for benign meningiomas, comparable to Gamma Knife surgery.
    • Minimum tumor dose exceeding 10 Gy is a significant factor for improved PFS.
    • Results support Linac-based SRS as an effective treatment modality for benign intracranial meningiomas.