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Related Experiment Videos

Decrease in analgesic effect of nifedipine following chronic morphine administration.

T Ohnishi1, K Saito, K Matsumoto

  • 1Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Osaka University, Suita, Japan.

European Journal of Pharmacology
|December 6, 1988
PubMed
Summary
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Nifedipine, a calcium channel blocker, showed reduced pain relief in morphine-tolerant mice. This suggests morphine

Area of Science:

  • Pharmacology
  • Neuroscience
  • Pain Research

Background:

  • Calcium ions play a crucial role in cellular signaling pathways.
  • Opioid analgesics, like morphine, are widely used for pain management.
  • Tolerance to morphine can develop with chronic use, reducing its efficacy.

Purpose of the Study:

  • To investigate the role of calcium influx in the analgesic effects of nifedipine.
  • To compare the efficacy of nifedipine in control versus morphine-tolerant mice.
  • To explore the relationship between morphine tolerance and calcium channel activity.

Main Methods:

  • Acetic acid-induced writhing test in mice.
  • Administration of nifedipine (a calcium antagonist).
  • Comparison between control and morphine-tolerant mouse models.

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Main Results:

  • Nifedipine demonstrated a reduced ability to inhibit the writhing syndrome in morphine-tolerant mice compared to control mice.
  • The analgesic effect of nifedipine was significantly diminished in the presence of morphine tolerance.
  • These findings indicate a potential link between calcium influx and morphine's mechanism of action.

Conclusions:

  • Inhibition of calcium influx is implicated in the analgesic action of morphine.
  • Chronic morphine administration may lead to an increased calcium entry into cells.
  • Calcium channel modulation could be a target for managing pain and opioid tolerance.