Nesfatin-1 in cardiovascular orchestration: From bench to bedside

Area of Science:

• Neuroendocrinology
• Cardiovascular Physiology

Background:

• Nesfatin-1, discovered in 2006, is derived from Nucleobindin 2.
• It influences appetite, water intake, and glucose homeostasis.
• Recent research suggests Nesfatin-1 impacts cardiovascular control.

Purpose of the Study:

• To systematically review the latest findings on Nesfatin-1.
• Focus on its cardiovascular regulatory properties in normal and pathological states.
• Establish Nesfatin-1 as a modulator of cardiovascular function and a factor in cardiovascular diseases.

Main Methods:

• Systematic literature review.
• Analysis of experimental evidence on Nesfatin-1's physiological functions.
• Focus on cardiovascular effects.

Main Results:

• Nesfatin-1 exhibits anorexic, water intake, and glucose homeostasis properties.
• Evidence indicates Nesfatin-1 influences central and peripheral cardiovascular control.
• A specific receptor for Nesfatin-1 is yet to be identified.

Conclusions:

• Nesfatin-1 is a pleiotropic neuroendocrine molecule.
• Nesfatin-1 acts as a homeostatic modulator of cardiovascular function.
• Nesfatin-1 may play a crucial role in cardiovascular diseases.