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Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.6K

Potential diagnostic and therapeutic value of circular RNAs in cardiovascular diseases

Jin-Yu Sun1, Yan Shi2, Xin-Yong Cai3

  • 1The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.

Cellular Signalling
|March 24, 2020
PubMed

Insights

Circular RNAs (circRNAs) show promise as novel biomarkers for early cardiovascular disease (CVD) detection and treatment. Research explores their diagnostic and therapeutic potential in various heart conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) present a significant global health challenge, with current diagnostic biomarkers limited by noncardiac influences.
  • Despite treatment advancements, patient outcomes, survival rates, and prognosis for CVDs remain suboptimal.
  • There is a critical need for innovative diagnostic and therapeutic approaches to enable early heart disease identification and reduce morbidity/mortality.

Purpose of the Study:

  • To introduce the biogenesis and functions of circular RNAs (circRNAs).
  • To elucidate the roles of circRNAs in various cardiovascular diseases, including atherosclerosis, coronary artery disease, myocardial infarction, and cardiomyopathy.
  • To provide an overview of current challenges and future directions for circRNA applications in CVD management.

Main Methods:

  • Review of existing literature on circRNA biogenesis and function.
  • Analysis of studies investigating circRNA roles in cardiovascular pathologies.
  • Synthesis of current challenges and future prospects in the field.

Main Results:

  • Circular RNAs (circRNAs) are increasingly recognized for their diverse biological functions beyond initial perceptions as splicing byproducts.
  • Emerging evidence highlights the significant roles of circRNAs in the pathogenesis and progression of multiple cardiovascular diseases.
  • Advancements in bioinformatics and sequencing technologies facilitate the study of circRNAs in complex diseases.

Conclusions:

  • CircRNAs represent a promising class of molecules with potential as novel diagnostic biomarkers and therapeutic targets for cardiovascular diseases.
  • Further research is essential to overcome current challenges and fully harness the diagnostic and therapeutic capabilities of circRNAs in cardiology.
  • Understanding circRNA mechanisms offers new avenues for improving early detection and treatment strategies for heart conditions.

Keywords:
Cardiovascular diseasesCircular RNADiagnosisTherapy

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