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Published on: July 3, 2013
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Chronic renal disease among lead-exposed workers
Kyle Steenland1, Vaughn Barry2
1Department of Environmental Health, Emory University, Atlanta, Georgia, USA nsteenl@emory.edu.
Occupational and Environmental Medicine
|March 24, 2020
Summary
Occupational lead exposure did not significantly increase kidney disease risk in male workers. Further research is needed to understand potential links in specific subgroups.
Area of Science:
- Environmental Health
- Occupational Medicine
- Nephrology
Background:
- High inorganic lead exposure is linked to severe kidney damage.
- Occupational lead exposure in male workers was previously studied.
Purpose of the Study:
- To investigate the long-term association between occupational lead exposure and end-stage renal disease (ESRD) incidence and mortality.
- To extend follow-up on a cohort of male workers with documented blood lead levels.
Main Methods:
- Extended follow-up for 7 years on a cohort of 58,307 male workers.
- Assessed mortality via the National Death Index and ESRD incidence using the US Renal Data System.
- Conducted internal analyses using Cox regression, adjusting for age, calendar time, and race.
Main Results:
- The cohort was followed for a median of 18 years, with 524 ESRD cases and 6527 deaths.
- No overall trend of increased ESRD or mortality was observed with higher blood lead levels.
- Inconsistent positive trends were noted for non-Caucasians and older men with prolonged follow-up (>15 years).
Conclusions:
- No significant association was found between higher occupational lead exposure and end-stage renal disease.
- Potential increased risks in non-Caucasians and older men were observed but were not statistically significant.
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