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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Updated: Dec 25, 2025

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
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Host resilience to emerging coronaviruses.

Amanda M Jamieson1

  • 1Department of Microbiology and Immunology, Brown University, Providence, RI, USA.

Future Virology
|March 24, 2020
PubMed
Summary
This summary is machine-generated.

This review explores host resilience mechanisms as potential treatments for severe respiratory infections like those caused by coronaviruses (severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus). Enhancing the host

Keywords:
ALIARDSMERS-CoVSARS-CoVcoronavirusdisease tolerancehost resiliencepulmonaryrespiratory infectionviral pathogenesis

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Area of Science:

  • Virology
  • Immunology
  • Respiratory Medicine

Background:

  • Emergence of severe coronaviruses (SARS-CoV and MERS-CoV) causing severe respiratory illness.
  • Lack of effective antiviral treatments and vaccines for these emerging zoonotic viruses.
  • Potential for future zoonotic coronavirus outbreaks necessitates novel therapeutic strategies.

Purpose of the Study:

  • To explore host resilience mechanisms for treating severe respiratory viral infections.
  • To identify strategies that enhance host tolerance to infections.
  • To review potential treatments for acute lung injury and acute respiratory distress syndrome caused by viruses.

Main Methods:

  • Literature review of host resilience mechanisms.
  • Analysis of host-pathogen interactions in respiratory viral infections.
  • Synthesis of findings on disease tolerance and recovery.

Main Results:

  • Host resilience mechanisms offer a promising avenue for therapeutic intervention.
  • Enhancing disease tolerance can mitigate severe outcomes of viral respiratory infections.
  • Understanding host responses is key to developing new treatments.

Conclusions:

  • Host resilience strategies could provide novel treatment options for severe respiratory viral diseases.
  • Further research into host mechanisms can lead to effective therapies against coronaviruses and other respiratory viruses.
  • Exploiting host resilience is crucial for managing current and future respiratory pandemics.