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Post-translational modifications of coronavirus proteins: roles and function
To Sing Fung1,1, Ding Xiang Liu1,2,1,2
1South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, & Integrative Microbiology Research Center, Guangzhou 510642, Guangdong, PR China.
Future Virology
|March 24, 2020
Summary
This review explores post-translational modifications (PTMs) in coronaviruses (CoVs). Understanding CoV protein PTMs is crucial for viral replication and pathogenesis research.
Area of Science:
- Virology
- Molecular Biology
- Biochemistry
Background:
- Post-translational modifications (PTMs) are essential for regulating protein function.
- Viruses, including coronaviruses (CoVs), utilize host cell machinery for replication and are subject to PTMs.
- CoVs are significant human and animal pathogens.
Purpose of the Study:
- To review current knowledge on PTMs of CoV proteins.
- To emphasize the impact of PTMs on viral replication and pathogenesis.
- To discuss CoV interference with host protein PTMs.
Main Methods:
- Literature review of studies on CoV protein PTMs.
- Analysis of PTMs on various CoV proteins (spike, envelope, membrane, nucleocapsid, nonstructural, accessory).
- Examination of the functional consequences of PTMs on viral processes.
Main Results:
- Numerous CoV proteins undergo diverse PTMs, including glycosylation, palmitoylation, phosphorylation, and ADP-ribosylation.
- These PTMs significantly influence viral replication and pathogenesis.
- Some CoVs can manipulate host protein PTMs.
Conclusions:
- PTMs are critical regulatory mechanisms for CoV proteins.
- Understanding CoV PTMs offers insights into viral mechanisms and potential therapeutic targets.
- Further research into CoV-host PTM interactions is warranted.
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