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Middle East respiratory syndrome: pathogenesis and therapeutic developments
Hani Choudhry1,1, Muhammed A Bakhrebah2,2, Wesam H Abdulaal1,1
1Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, Cancer & Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Middle East respiratory syndrome coronavirus (MERS-CoV), identified in 2012, is a significant public health threat with no current vaccines. This review covers MERS-CoV pathogenesis, treatments, and prevention strategies.
Area of Science:
- Virology
- Public Health
- Infectious Diseases
Background:
- Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012.
- Over 2200 cases reported by 2018, primarily in Saudi Arabia.
- High mortality rate and lack of effective treatments pose significant public health challenges.
Purpose of the Study:
- To review current knowledge on MERS-CoV.
- To summarize pathogenesis, transmission, and pathophysiology.
- To highlight advancements in vaccines, therapeutics, and control measures.
Main Methods:
- Literature review of MERS-CoV research.
- Synthesis of information on viral characteristics.
- Analysis of therapeutic and vaccine development.
Main Results:
- Comprehensive overview of MERS-CoV.
- Discussion of existing and emerging treatment options.
- Summary of prevention and control efforts.
Conclusions:
- MERS-CoV remains a critical global health concern.
- Ongoing research is vital for developing effective countermeasures.
- Integrated strategies are needed for MERS prevention and control.
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