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Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining
Qiu-Ting Li1, Zao-Zao Huang2, Yao-Bin Chen3
1Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.
Abstract:
Objective: Cancer is expected to be the leading cause of death worldwide within the 21st century and is the single most important obstacle to extending life expectancy. Unfortunately, the most effective approach to combating cancers remains a complex and unsolved problem. Siglec-15 is a member of the Siglec family and plays a conserved regulatory role in the immune system of vertebrates. Previous studies on Siglec-15 have focused on its function in osteoclast regulation. The purpose of this study was to explore the significance of Siglec-15 mRNA in human cancer mainly based on information obtained from online databases. Method: Data were collected from several online databases. Serial analysis of gene expression (SAGE) and Virtual Northern, UALCAN Database Analysis, Catalog of Somatic Mutations in Cancer (COSMIC) analysis, the cBio cancer genomics portal, Cancer Regulome tools and data, Kaplan-Meier Plotter Analysis and the UCSC Xena website were used to analyze the data. Results: Compared with normal tissues, Siglec-15 up-regulation was widely observed in tuomrs. Differences in Siglec-15 expression were associated with different prognoses. Siglec-15 mutations are widely observed in tumors and interact with different genes in different cancer types. Conclusion: Siglec-15 is a potential target for the expansion of cancer immunotherapy.
Insights
Siglec-15 messenger RNA (mRNA) is upregulated in many human cancers and linked to patient prognosis. This suggests Siglec-15 is a potential target for developing novel cancer immunotherapies.
Area of Science:
- Immunology
- Genomics
- Oncology
Background:
- Cancer remains a leading cause of death globally, necessitating new therapeutic strategies.
- Siglec-15, a member of the Siglec family, has a known role in immune system regulation, particularly in osteoclast function.
- Previous research on Siglec-15 has primarily focused on its role in osteoclast biology.
Purpose of the Study:
- To investigate the significance of Siglec-15 messenger RNA (mRNA) expression in human cancers.
- To analyze Siglec-15's role in cancer development and progression using publicly available data.
Main Methods:
- Utilized multiple online databases including Serial Analysis of Gene Expression (SAGE), UALCAN, Catalog of Somatic Mutations in Cancer (COSMIC), cBio cancer genomics portal, Cancer Regulome, Kaplan-Meier Plotter, and UCSC Xena.
- Analyzed gene expression, mutation data, and patient survival information.
Main Results:
- Siglec-15 mRNA was found to be significantly upregulated in various tumor types compared to normal tissues.
- Siglec-15 expression levels correlated with patient prognosis, indicating its clinical relevance.
- Siglec-15 mutations were frequently observed in tumors and showed interactions with different genes across diverse cancer types.
Conclusions:
- Siglec-15 is frequently dysregulated in human cancers.
- Siglec-15 represents a promising potential target for advancing cancer immunotherapy strategies.
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