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Updated: Dec 25, 2025
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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
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Atherosclerosis Can Be Mitochondrial: A Review.
1Neurology, Krankenanstalt Rudolfstiftung, Vienna, AUT.
Cureus
|March 24, 2020
Summary
Mitochondrial disorders can cause atherosclerosis, a condition often overlooked in arteries. Early intervention with antioxidants and cofactors alongside standard treatments is crucial for patients with mitochondrial atherosclerosis.
Area of Science:
- Cardiovascular Medicine
- Mitochondrial Biology
- Genetics
Background:
- Arteries are often overlooked in mitochondrial disorders, despite atherosclerosis being a potential manifestation.
- Mitochondrial disorders can lead to atherosclerosis through primary mechanisms or secondary to conditions like diabetes and hypertension.
Purpose of the Study:
- To review current knowledge on mitochondrial atherosclerosis.
- To highlight recent advances in understanding and managing this condition.
Main Methods:
- A systematic literature review was conducted using PubMed.
- Search terms focused on mitochondrial disorders and atherosclerosis.
Main Results:
- Atherosclerosis can be a primary feature of mitochondrial disorders, particularly in patients with mtDNA gene mutations.
- Potential mechanisms include oxidative stress, mitophagy, metabolic dysfunction, and lactic acidosis.
- Atherosclerosis may occur independently of traditional risk factors, suggesting a direct link to metabolic defects.
Conclusions:
- Mitochondrial atherosclerosis requires specific management, including antioxidants and cofactors, in addition to antithrombotic therapy.
- Further systematic investigation is needed to fully understand and treat primary mitochondrial atherosclerosis.
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