Related Experiment Video
Updated: Dec 25, 2025
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
3.1K
Early puberty and risk for type 2 diabetes in men
Claes Ohlsson1,2, Maria Bygdell1, Maria Nethander1,3
1Centre for Bone and Arthritis Research, Institute of Medicine, the Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, Sahlgrenska University Hospital, S-413 45, Gothenburg, Sweden.
Diabetologia
|March 24, 2020
Summary
Early puberty is a significant independent risk factor for developing type 2 diabetes in men. This finding suggests puberty timing, not just BMI, influences future diabetes risk.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Epidemiology
Background:
- The relationship between pubertal timing and type 2 diabetes risk, independent of childhood BMI, remains unclear.
- Understanding this association is crucial for identifying individuals at higher risk for adult-onset diabetes.
Purpose of the Study:
- To investigate the association between pubertal timing and the risk of adult-onset type 2 diabetes in Swedish men.
- To determine if this association persists independently of prepubertal Body Mass Index (BMI).
Main Methods:
- Utilized data from 30,697 Swedish men with BMI at ages 8 and 20, and age at Peak Height Velocity (PHV) as a pubertal timing marker.
- Type 2 diabetes diagnoses (n=1851) were obtained from the Swedish National Patient Register.
- Cox regression analysis was employed, with follow-up split to account for non-proportional hazards.
Main Results:
- Earlier age at PHV was inversely associated with both early and late type 2 diabetes diagnosis.
- These associations remained significant after adjusting for childhood BMI.
- Early PHV also predicted the need for insulin treatment in type 2 diabetes patients.
Conclusions:
- Early puberty emerges as a novel, independent risk factor for type 2 diabetes.
- Approximately 15% of type 2 diabetes cases could potentially be avoided if individuals did not experience early puberty.
Keywords:
Childhood BMICohortEndocrinologyEpidemiologyNational registersPaediatricsPubertySchool health recordsType 2 diabetesMore Related Videos
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
01:27Signs of Puberty
1.2K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.2K
01:15Diabetes: Symptoms, Diagnosis, and Complications
1.9K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.9K
01:36Carbohydrate Metabolism
13.6K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.6K
01:22Diabetes Mellitus: Overview and Type I Subtype
4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K
01:19Psychoneuroimmunology: Diabetes and Cancer
363
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
363