Related Experiment Video
Updated: Dec 25, 2025

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
Histological type and typing of breast carcinomas and the WHO classification changes over time
Gábor Cserni1,2
1Bács-Kiskun County Teaching Hospital, Department of Pathology, Kecskemét, Hungary.
Abstract:
The World Health Organization's new classification of breast tumors has just been published. This review aims to examine the morphological categorization of breast carcinomas which is still principally based on histological features and follows the traditions of histological typing. It gives a subjective and critical view on the WHO classifications and their changes over time, and describes the changes related to some of the most common or challenging breast carcinomas: in situ carcinomas, invasive breast carcinomas of no special type, lobular, cribriform, tubular, mucinous, papillary, metaplastic carcinomas and carcinomas with medullary pattern and those with apocrine differentiation are discussed in more details. Although the 5th edition of the classification is not perfect, it has advantages which are mentioned along with problematic issues of classifications.
Related Concept Videos
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Classification of Epithelial Tissues: Overview
Based on the number of cell layers,...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Classification of Epithelial Tissues: Glandular Epithelium
Multicellular glands are formed during early development when epithelial budding...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Classification of Epithelial Tissues: Stratified Epithelium

