Related Experiment Video

Updated: Dec 25, 2025

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

9.4K

Epilepsy surgery reduced seizure frequency for patients with severe motor and intellectual disorders

Ayataka Fujimoto1, Tohru Okanishi1, Naoki Ichikawa1

  • 1Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Japan.

Epilepsy & Behavior : E&B
|March 24, 2020
PubMed

Insights

Epilepsy surgery significantly reduced seizure frequency in pediatric patients with severe motor and intellectual disorders. This intervention also improved status epilepticus, offering hope for improved seizure control in this challenging population.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Neurosurgery

Background:

  • Epilepsy surgery outcomes for patients with severe motor and intellectual disorders (SMIDs) are not well-documented.
  • Understanding the impact of surgical interventions is crucial for this vulnerable patient group.

Purpose of the Study:

  • To evaluate the efficacy of epilepsy surgery in reducing seizure frequency in pediatric patients with SMIDs.
  • To assess changes in antiseizure medication (ASM) use and comorbidities post-surgery.

Main Methods:

  • Retrospective analysis of 288 pediatric epilepsy surgeries (2009-2018).
  • Inclusion criteria: Oshima classification 1, age ≥2 years, documented ictal events, ≥1-year follow-up.
  • Comparison of pre- and post-operative seizure frequency, ASM count, and respiratory/feeding status.

Main Results:

  • Nineteen patients (ages 2-12) met criteria; 16 underwent vagus nerve stimulation, 2 corpus callosotomy, 1 focus resection.
  • Significant reduction in seizure frequency (p=0.029) and status epilepticus (p=0.046) observed post-surgery.
  • No significant change in the number of ASMs (p=0.728).

Conclusions:

  • Epilepsy surgery is effective in reducing seizure frequency in pediatric patients with SMIDs.
  • Surgical interventions can improve seizure control and reduce status epilepticus, even in patients with significant comorbidities.
  • Further research into tailored surgical approaches for SMID patients is warranted.
Abstract

Keywords:
Epilepsy surgeryGeneral conditionSeizure frequencySevere motor and intellectual disorders (SMIDs)Status epilepticus

More Related Videos

Performing Behavioral Tasks in Subjects with Intracranial Electrodes12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.7K
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.7K

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.5K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
737
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.2K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
806
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.1K