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Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review
Sidney J Stohs1, Oliver Chen2, Sidhartha D Ray3
1School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA.
Molecules (Basel, Switzerland)
|March 25, 2020
Summary
New curcumin formulations significantly improve absorption, overcoming poor solubility and rapid metabolism. This enhances its potential for health benefits and therapeutic applications, making curcumin a more effective dietary supplement.
Area of Science:
- Pharmacology and Nutraceutical Science
- Bioavailability and Formulation Science
Background:
- Curcumin possesses diverse beneficial properties like antioxidant, anti-inflammatory, and neuroprotective effects.
- Poor solubility, low absorption, and rapid metabolism limit curcumin's therapeutic utility.
- Micro- and nano-formulations offer enhanced bioavailability, addressing these limitations.
Purpose of the Study:
- To review advancements in curcumin formulations that enhance bioavailability.
- To discuss curcumin metabolism, solubility-particle size relationships, and pharmacokinetic studies.
- To evaluate current applications and future directions for formulated curcumin.
Main Methods:
- Review of scientific literature on curcumin bioavailability and formulations.
- Analysis of pharmacokinetic studies involving enhanced curcumin products.
- Discussion of analytical methods for curcumin quantification.
Main Results:
- Advanced micro- and nano-formulations significantly improve curcumin absorption and blood levels.
- Formulation strategies are crucial for overcoming curcumin's inherent bioavailability challenges.
- Human pharmacokinetic data support the efficacy of bioavailable curcumin formulations.
Conclusions:
- Enhanced curcumin formulations unlock its full therapeutic potential for various health applications.
- Further research into bioavailable curcumin is warranted for pain management and tissue protection.
- Optimized formulations are key to realizing curcumin's promise as a health-promoting agent.
Keywords:
absorptionapplicationsbioavailabilitycurcumincurcumin metaboliteshydrolysismechanisms of actionsolubilitytetrahydrocurcuminMore Related Videos
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