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Cannabidiol in sport: Ergogenic or else?

François-Xavier Gamelin1, Gregory Cuvelier2, Antoine Mendes1

  • 1Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, F-59000 Lille, France.

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Cannabidiol (CBD), a non-intoxicating cannabis compound, shows potential benefits for athletes, including anti-inflammatory and analgesic effects. However, clinical data on CBD use in exercise is currently lacking, making its application premature.

Keywords:
AnxiolyticCannabidiolCannabisDopingNeuroprotectiveSleep-wake cycle

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Area of Science:

  • Sports Science
  • Pharmacology
  • Cannabinoid Research

Background:

  • Cannabis and its compounds are regulated in sports, with Δ9-tetrahydrocannabinol prohibited by the World Anti-Doping Agency (WADA) since 2004.
  • Cannabidiol (CBD), a non-intoxicating phytocannabinoid, has gained attention for its potential therapeutic properties.
  • WADA removed CBD from its list of prohibited substances in 2018, opening possibilities for its use by athletes.

Purpose of the Study:

  • To review preclinical findings on CBD's properties relevant to athletes.
  • To discuss the potential utility of CBD in the sports domain.
  • To highlight the need for clinical research on CBD and exercise.

Main Methods:

  • Review of preclinical studies on CBD.
  • Analysis of CBD's pharmacological properties.
  • Discussion of regulatory status and WADA guidelines.

Main Results:

  • Preclinical research suggests CBD possesses anti-inflammatory, analgesic, anxiolytic, and neuroprotective properties.
  • CBD may influence the sleep-wake cycle, potentially benefiting athletes.
  • Limited clinical data exists regarding CBD's effects in the context of physical exercise.

Conclusions:

  • CBD exhibits promising properties for athletic applications based on preclinical data.
  • Further clinical investigation is essential to validate CBD's efficacy and safety for athletes.
  • Current evidence suggests that the use of CBD in sports remains premature due to a lack of human studies.