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Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses
1Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina, USA sean@collaborationspharma.com peter.madrid@sri.com.
Abstract:
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV).
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