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Ectopic Lacrimal Gland Tissue: A Systematic Review
Sonali Nagendran1, Mazen Alsamnan2, Diego Strianese2
1Queen Victoria Hospital, East Grinstead, United Kingdom.
Ophthalmic Plastic and Reconstructive Surgery
|March 25, 2020
Summary
Ectopic lacrimal gland tissue is a rare condition presenting as masses, most commonly on the epibulbar conjunctiva. This tissue can mimic other tumors and may undergo neoplastic transformation, necessitating careful diagnosis and complete excision.
Area of Science:
- Ophthalmology
- Pathology
- Head and Neck Surgery
Background:
- Ectopic lacrimal gland tissue is an uncommon condition where lacrimal gland tissue is found outside its normal anatomical location.
- It can present as a mass in various ocular and periocular regions, potentially mimicking other pathologies.
Purpose of the Study:
- To review the clinical and histopathological findings of ectopic lacrimal gland tissue.
- To enhance understanding of its presentation, location, histology, and potential for neoplastic transformation.
Main Methods:
- A systematic review of English-language, peer-reviewed literature was conducted.
- Studies meeting clinical and histopathological criteria for ectopic lacrimal gland tissue were included.
Main Results:
- 180 cases were identified from 69 publications (1946-2018), with males slightly more affected (57%).
- The most common location was epibulbar conjunctiva (62%), presenting as a mass or proptosis.
- Histologically, choristomas were most frequent (94%), with rare neoplastic transformations reported.
Conclusions:
- Ectopic lacrimal gland tissue is a rare differential diagnosis for ocular and periocular masses, especially in children.
- It shares susceptibility to neoplastic transformation with normal lacrimal glands.
- Complete excision is crucial to prevent recurrence, as incomplete removal can lead to regrowth.
