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Identification of Circular RNAs using RNA Sequencing
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Circular RNA-protein interactions: functions, mechanisms, and identification.

Anqing Huang1, Haoxiao Zheng1, Zhiye Wu2

  • 1Department of Cardiology, Shunde Hospital, Southern Medical University, Jiazhi Road, Lunjiao Town, Shunde District, Foshan, 528300, China.

Theranostics
|March 25, 2020
PubMed
Summary

Circular RNAs (circRNAs) are versatile molecules with diverse functions, including acting as protein sponges. This review explores circRNA-protein interactions, their mechanisms, and identification methods.

Keywords:
RNA binding proteins (RBPs)biogenesiscircular RNAs (circRNAs)degradationtranslation

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are non-linear RNA molecules with unique structures.
  • Initially dismissed as splicing errors, circRNAs are now recognized for significant biological roles.
  • They function as miRNA sponges, protein sponges, decoys, scaffolds, and even translation templates.

Purpose of the Study:

  • To review current knowledge on circRNA-protein interactions.
  • To discuss methods for identifying and characterizing these interactions.
  • To summarize new insights into the mechanisms of circRNA-protein binding.

Main Methods:

  • Literature review of recent studies on circRNA-protein interactions.
  • Analysis of experimental techniques used to identify and characterize these interactions.
  • Synthesis of current understanding of the functional implications of circRNA-protein binding.

Main Results:

  • CircRNAs interact with proteins, influencing their localization and function.
  • Proteins are crucial for circRNA biogenesis and degradation.
  • The precise mechanisms governing circRNA-protein interactions are still under investigation.
  • Various methods exist for identifying and characterizing circRNA-protein interactions.

Conclusions:

  • CircRNA-protein interactions are fundamental to various cellular processes.
  • Understanding these interactions is key to elucidating circRNA functions in health and disease.
  • Further research is needed to fully uncover the mechanisms and implications of circRNA-protein interplay.