Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

5.4K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.4K
Vaccinations01:51

Vaccinations

50.9K
Overview
50.9K
Active versus Passive Immunity01:31

Active versus Passive Immunity

9.7K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
9.7K
Hybridoma Technology01:31

Hybridoma Technology

17.0K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
17.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.1K
Overview
83.1K
Humoral Immune Responses01:36

Humoral Immune Responses

83.0K
Overview
83.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foundation model cascades enable zero-shot microscopy image analysis for cell therapy manufacturing.

Cytotherapy·2026
Same author

Nondestructive, High-Resolution T Cell Characterization and Subtyping via Deep-UV Microscopy.

BME frontiers·2026
Same author

Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors.

bioRxiv : the preprint server for biology·2026
Same author

Protease-Activated Plasmonic Nanosensors for Predictive Ultrasound-Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

An integrated ultrasound-guided focused ultrasound system enables spatiotemporal control of thermal gene activation in engineered immune cells.

Theranostics·2025
Same author

Label-free in-line characterization of immune cell culture using quantitative phase imaging.

NPJ Regenerative medicine·2025

Related Experiment Video

Updated: Dec 25, 2025

Synthetic Antigen Controls for Immunohistochemistry
09:30

Synthetic Antigen Controls for Immunohistochemistry

Published on: August 23, 2021

2.9K

Synthetic immunity by remote control.

Lena Gamboa1, Ali H Zamat1, Gabriel A Kwong1,2,3,4,5

  • 1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332, USA.

Theranostics
|March 25, 2020
PubMed
Summary
This summary is machine-generated.

Remote control technologies enhance cell-based immunotherapies like CAR T cells by precisely managing T cell functions. This improves treatment efficacy and safety, offering new possibilities for treating various diseases.

Keywords:
engineered cellsgene switchesimmunotherapyremote controlsynthetic immunity

More Related Videos

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

764
Murine Model of Epicutaneously-Induced Immunomodulation
09:06

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

364

Related Experiment Videos

Last Updated: Dec 25, 2025

Synthetic Antigen Controls for Immunohistochemistry
09:30

Synthetic Antigen Controls for Immunohistochemistry

Published on: August 23, 2021

2.9K
Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

764
Murine Model of Epicutaneously-Induced Immunomodulation
09:06

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

364

Area of Science:

  • Immunology
  • Biotechnology
  • Oncology

Background:

  • Cell-based immunotherapies, including chimeric antigen receptor (CAR) T cells, show promise for treating refractory diseases.
  • Controlling T cell potency is crucial for managing treatment efficacy and preventing adverse effects like cytokine release syndrome or immunosuppression.

Purpose of the Study:

  • To review emerging technologies for the remote, site-targeted control of immune cell functions.
  • To highlight the potential of these technologies to enhance precision and safety in cell-based immunotherapies.

Main Methods:

  • Review of current literature on remote control technologies for immune cell functions.
  • Discussion of technologies enabling control over T cell proliferation, antigen-sensing, and target-cell killing.

Main Results:

  • Emerging technologies offer site-targeted, remote control over key T cell functions.
  • These technologies can overcome limitations of conventional drugs, such as mass transport barriers and lack of specificity.

Conclusions:

  • Remote control of synthetic immunity presents significant opportunities for advancing cell-based therapies.
  • These technologies are broadly applicable to various immune cells and diseases, including cancers.