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Updated: Dec 25, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study
Pasquale Linciano1, Barbara De Filippis2, Alessandra Ammazzalorso2
1Department of Life Sciences , University of Modena , via Giuseppe Campi 103 , 41125 Modena , Italy.
Abstract:
PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB. In this study, we assayed some PPAR agonists previously synthesized by us for their physicochemical properties, with particular references to lipophilicity, solubility and permeability profiles, using the PAMPA. Although tested compounds showed high lipophilicity and low aqueous solubility, the results revealed a good overall druggability profile, encouraging further studies in the field of neurodegenerative diseases.
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