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Updated: Dec 25, 2025

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Chronic Corynebacterium striatum Septic Arthritis in a Patient Referred for Total Knee Arthroplasty
Katharine Hollnagel1, Jacob Willen1, Michael Ellis2
1Department of Orthopaedic Surgery, The University of Toledo Medical Center, USA.
Background:
While Corynebacterium striatum and other Corynebacterium species were historically considered contaminants, they are recently being identified as pathogens with increasing frequency. Case Summary. We report the case of a 78-year-old gentleman with a three-year history of knee pain and established diagnosis of osteoarthritis referred for consideration for total knee arthroplasty. He had no knee pain with passive range-of-motion. Plain films demonstrated bony erosions atypical for osteoarthritis. Joint aspiration white blood cell count was 30,548/mm3, but multiple cultures were positive for C. striatum. The infection was successfully treated with open irrigation and debridement, complete synovectomy, and six weeks of intravenous daptomycin.
Conclusion:
To our knowledge, this is the first report of chronic C. striatum septic arthritis of a native joint and only the third case of C. striatum septic arthritis of the knee.C. striatum. The infection was successfully treated with open irrigation and debridement, complete synovectomy, and six weeks of intravenous daptomycin. C. striatum. The infection was successfully treated with open irrigation and debridement, complete synovectomy, and six weeks of intravenous daptomycin.
Insights
Corynebacterium striatum is increasingly recognized as a pathogen. This case highlights successful treatment of chronic C. striatum septic arthritis in a native knee joint using surgery and daptomycin.
Area of Science:
- Infectious Diseases
- Orthopedic Surgery
- Microbiology
Background:
- Corynebacterium striatum, once considered a contaminant, is now frequently identified as a pathogen.
- Septic arthritis is a serious joint infection that requires prompt diagnosis and treatment.
- Osteoarthritis is a common degenerative joint disease often treated with total knee arthroplasty.
Observation:
- A 78-year-old male with osteoarthritis presented with chronic knee pain and atypical bony erosions on plain films.
- Joint aspiration revealed a high white blood cell count (30,548/mm3) and positive cultures for C. striatum.
- The patient had no pain with passive range-of-motion, which is unusual for septic arthritis.
Findings:
- This is the first reported case of chronic C. striatum septic arthritis in a native joint.
- It is only the third reported case of C. striatum septic arthritis affecting the knee.
- Successful treatment involved open irrigation and debridement, synovectomy, and six weeks of intravenous daptomycin.
Implications:
- Highlights the emerging role of C. striatum as a pathogen in joint infections.
- Demonstrates the efficacy of surgical intervention and daptomycin in treating chronic C. striatum septic arthritis.
- Suggests considering C. striatum in the differential diagnosis of atypical septic arthritis, even in native joints.
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