Related Experiment Video
Updated: Dec 25, 2025

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
Spontaneous Pneumomediastinum and Diffuse Subcutaneous Emphysema after Methamphetamine Inhalation
Michael Agustin1, Gabriel David1, Ji Yeong Kang1
1Guam Regional Medical City, 133 Route 3, Dededo, Guam, USA 96929.
Inhaling methamphetamine can cause spontaneous pneumomediastinum and severe subcutaneous emphysema, leading to serious respiratory issues. This case highlights the acute lung injury risks associated with methamphetamine abuse.
Area of Science:
- Pulmonology
- Toxicology
- Emergency Medicine
Background:
- Methamphetamine is a potent stimulant drug with high abuse potential.
- Respiratory complications, including lung damage, are known risks of inhaled and intravenous methamphetamine use.
Observation:
- A case report details a patient experiencing spontaneous pneumomediastinum and severe subcutaneous emphysema.
- These respiratory conditions occurred following the inhalation of methamphetamine.
Findings:
- Inhalation of methamphetamine can lead to alveolar rupture and air dissection within the chest.
- Severe subcutaneous emphysema, potentially compromising the airway, can develop from pneumomediastinum.
Implications:
- This case underscores the critical need to recognize acute respiratory complications associated with methamphetamine use.
- Healthcare providers should consider methamphetamine inhalation as a potential cause of spontaneous pneumomediastinum and emphysema.
Related Concept Videos
Pneumothorax-II
Clinical Manifestations:
Pneumothorax-I
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Pulmonary Cycle: Exhalation
Pneumonia II: Pathophysiology
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation

