Mental Health Disorders Associated with Sinonasal and Skull Base Malignancies: A Large Cohort Study

Objective  The main purpose of this article is to examine the prevalence, incidence, sociodemographic, and clinical characteristics of mental health disorders (MHDs) among patients with skull base malignancies. Design  Retrospective cohort study. Settings/Participants  Six-thousand seven-hundred sixty sinonasal/skull base cancer patients in the MarketScan database between 2005 and 2014. Main Outcome Measures  Frequency of MHDs pre- and post-diagnosis in patients harboring sinonasal/skull base malignancies. Results  A significant increase in MHDs was noted from pre- to post-cancer diagnosis (22 vs 31%, p  < 0.0001). Despite an increase in the prevalence rate, the demographic profile of patients with MHDs post-diagnosis remained similar to pre-diagnosis. Those patients harboring MHDs were, however, more likely to be women (62.7 vs 47.4%), and carry a history of smoking (40.9 vs 26.3%) than those without MHDs. These comparisons were statistically significant ( p  < 0.0001). Conclusion  The prevalence of MHDs increases following a diagnosis of a sinonasal/skull base malignancy. Patients with MHDs were more likely to be women and smokers.