Cardiovascular risk and mortality in patients with active and treated hypercortisolism

Related Experiment Video

Updated: Dec 25, 2025

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.9K

Dingfeng Li1, Omar M El Kawkgi1, Andres F Henriquez1

  • 1Division of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, MN, USA.

Gland Surgery
|March 25, 2020
PubMed

Insights

Hypercortisolism significantly increases cardiovascular risks like hypertension and obesity, leading to higher mortality. While treatment helps, the cardiovascular risk is not fully reversed, highlighting the need for ongoing management.

Area of Science:

  • Endocrinology
  • Cardiology
  • Metabolic Disorders

Background:

  • Hypercortisolism is associated with substantial cardiovascular morbidity and mortality.
  • Delayed diagnosis exacerbates cardiovascular and metabolic complications.
  • Key comorbidities include hypertension, impaired glucose metabolism, dyslipidemia, and obesity.

Purpose of the Study:

  • To review the prevalence and mechanisms of cardiovascular comorbidities in hypercortisolism.
  • To summarize the impact of therapy on cardiovascular risk factors, events, and mortality.

Main Methods:

  • Literature review of studies on hypercortisolism and cardiovascular health.
  • Analysis of mechanisms underlying cardiovascular complications.
  • Evaluation of treatment effects on cardiovascular outcomes.

Main Results:

  • Hypercortisolism patients exhibit a high prevalence of cardiovascular risk factors.
  • These factors contribute to an increased incidence of cardiovascular events and mortality.
  • Therapeutic interventions reduce, but do not eliminate, this elevated cardiovascular risk.

Conclusions:

  • Cardiovascular complications are a major concern in hypercortisolism.
  • Effective management of hypercortisolism is crucial for mitigating cardiovascular risk.
  • Long-term cardiovascular monitoring is recommended even after successful treatment.

Keywords:
Cushing syndrome (CS)cardiovascular eventsdyslipidemiaglucose metabolismhypertensionmild autonomous cortisol secretion (MACS)

More Related Videos

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

10.0K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.7K

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
281
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.7K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
289
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.8K
Increased pulse rate01:17

Increased pulse rate

Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
978
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
654