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Determinants of Circulating Soluble Leptin Receptor and Free Leptin Index in Indonesian Pre-Pubertal Obese Male

Aryono Hendarto1, Dimple G Nagrani1, Anna Meiliana2

  • 1Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Pediatric Gastroenterology, Hepatology & Nutrition
|March 25, 2020
PubMed

Insights

In obese prepubertal boys, body fat and carbohydrate intake influence leptin regulation. Lowering body mass index (BMI), fat mass, and carbohydrate intake is key for preventing leptin resistance.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Obesity Research

Background:

  • Leptin resistance is a growing concern in childhood obesity.
  • Understanding leptin regulation is crucial for effective intervention strategies.
  • Soluble leptin receptor (CSLR) and free leptin index (FLI) are key markers of leptin bioavailability.

Purpose of the Study:

  • To identify clinical and metabolic factors affecting CSLR and FLI in obese prepubertal males.
  • To explore the relationship between body composition, diet, and leptin regulation.
  • To assess the role of lipid profiles and insulin resistance in leptin signaling.

Main Methods:

  • Cross-sectional study of 80 obese male children (5-9 years old).
  • Assessment of body mass index (BMI), body fat mass, and dietary intake (carbohydrates, fats).
  • Measurement of CSLR, FLI, lipid profiles, and insulin resistance (HOMA-IR).

Main Results:

  • BMI and body fat mass showed weak correlations with CSLR and FLI.
  • Carbohydrate intake was independently associated with CSLR levels.
  • Increased carbohydrate intake correlated with progressively decreased CSLR.

Conclusions:

  • Leptin regulation in obese prepubertal boys is linked to body composition and diet.
  • Carbohydrate intake is a significant predictor of CSLR.
  • Interventions should target BMI, fat mass, and carbohydrate reduction to manage leptin resistance.
Abstract

Keywords:
Body fat massBody mass indexCirculating soluble leptin receptorDietFree leptin indexInsulin resistanceLipid

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