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Computer-Aided Design and Manufacturing (CAD/CAM) for Bioprinting
1SMART Infrastructure Facility, Faculty of Engineering & Information Sciences, University of Wollongong, Wollongong, NSW, Australia. cfay@uow.edu.au.
Methods in Molecular Biology (Clifton, N.J.)
|March 25, 2020
Summary
3D bioprinting aims to create functional human tissues and organs using advanced technology and bioinks. This review explores the crucial role of medical imaging, computer-aided design, and manufacturing in achieving this goal.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Tissue Engineering
Background:
- Three-dimensional (3D) bioprinting of human tissues and organs has been researched for nearly three decades.
- The primary objective is to achieve fully functional printed tissues and organs.
- Technological advancements, particularly in bioinks and computer-aided design and manufacturing (CAD/CAM), are critical for success.
Purpose of the Study:
- This chapter focuses on the technology underpinning 3D bioprinting.
- It explores the integration of medical imaging in the bioprinting process.
- The review covers the extraction, classification, modeling, and simulation of tissue types from 3D scans.
Main Methods:
- Review of existing literature and technologies in 3D bioprinting.
- Discussion of medical imaging techniques for tissue and organ data acquisition.
- Analysis of computer-aided design (CAD) and computer-aided manufacturing (CAM) in bioprinting workflows.
- Exploration of data transfer from 3D models to bioprinters.
Main Results:
- Medical imaging is integral to bioprinting, enabling precise data acquisition for tissue and organ constructs.
- Computer-aided systems (CAD/CAM) are essential for designing, modeling, simulating, and manufacturing bioprinted tissues.
- The process involves extracting and classifying tissue types from 3D scans and transferring models to printers.
Conclusions:
- Significant technological advancements, including bioinks and CAD/CAM, are driving progress in 3D bioprinting.
- The integration of medical imaging and sophisticated modeling is key to creating functional tissue and organ constructs.
- Despite progress, challenges remain in achieving fully functional 3D-printed human tissues and organs.
