Related Experiment Video

Updated: Dec 25, 2025

A Proximal Culture Method to Study Paracrine Signaling Between Cells
08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

9.9K

The Effect of Metadherin on NF-κB Activation and Downstream Genes in Ovarian Cancer

Chunhong Rong1, Yanfen Shi1, Jun Huang1

  • 1Department of Pathology, China-Japan Friendship Hospital, Beijing, China.

Cell Transplantation
|March 25, 2020
PubMed

Insights

Metadherin (MTDH) is overexpressed in ovarian cancer (OC) and drives tumor progression by increasing inflammatory cytokines. Targeting the MTDH and NF-kappa-B (NF-κB) signaling network may offer new ovarian cancer treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Ovarian cancer (OC) remains a leading cause of cancer-related deaths due to its aggressive nature and limited therapeutic options.
  • Identifying novel molecular targets is crucial for developing effective treatments for OC.
  • Metadherin (MTDH), a multifunctional gene, has been implicated in various cancers but its role in OC was previously unexplored.

Purpose of the Study:

  • To investigate the role of metadherin (MTDH) in ovarian cancer (OC).
  • To identify MTDH as a potential therapeutic target for OC.

Main Methods:

  • Analysis of MTDH expression in OC tissues.
  • In vitro assays using cells with stable MTDH overexpression.
  • Measurement of cytokine expression (TNF-α, IL-6, IL-8, IL-10, IL-1β).
  • Investigation of the relationship between MTDH and NF-kappa-B (NF-κB) signaling.

Main Results:

  • MTDH was found to be overexpressed in OC tissues.
  • Stable MTDH overexpression significantly increased the expression of key inflammatory cytokines: TNF-α, IL-6, IL-8, IL-10, and IL-1β.
  • A feed-forward loop was identified between MTDH and NF-κB signaling.

Conclusions:

  • The MTDH and NF-κB signaling network plays a significant role in promoting OC traits.
  • MTDH is a novel OC-associated gene with potential implications for understanding OC biology.
  • MTDH represents a promising new therapeutic target for ovarian cancer treatment strategies.
Keywords:
NF-κBchronic inflammationmetadherinovarian cancer

More Related Videos

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.1K
Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity09:00

Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity

Published on: December 31, 2015

27.0K

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.7K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K