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[Genetic characteristics of stroke]
L T Khasanova1, L V Stakhovskaya1, E A Koltsova1
1Pirogov Russian National Research Medical University, Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|March 25, 2020
Summary
Genetic factors significantly influence stroke risk, impacting inflammation, coagulation, and metabolism. Identifying these genetic markers can help predict high-risk individuals for early stroke prevention.
Area of Science:
- Genetics and Neurology
- Cardiovascular Research
Background:
- Growing evidence highlights the significant role of genetic factors in stroke susceptibility.
- Both hemorrhagic and ischemic stroke risk are influenced by inherited predispositions.
Purpose of the Study:
- To review key genes and polymorphisms associated with stroke risk.
- To emphasize the importance of genetic analysis in understanding stroke etiology.
Main Methods:
- Literature review of genetic factors implicated in stroke.
- Analysis of gene polymorphisms affecting biological pathways relevant to stroke.
Main Results:
- Identified genetic factors modulate critical pathways including inflammation, coagulation, lipid metabolism, nitric oxide (NO) formation, and the renin-angiotensin-aldosterone system.
- Genetic variations contribute to overall homeostasis, influencing stroke susceptibility.
Conclusions:
- Comprehensive genetic analysis aids in identifying individuals at exceptionally high risk for stroke.
- Timely implementation of preventive strategies based on genetic profiling can reduce the overall burden of stroke.
