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Updated: Dec 25, 2025
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
[Surgical treatment patients with drug-resistant unilateral MRI-positive temporal forms of epilepsy]
V V Krylov1, A B Guekht2, I S Trifonov3
1Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia; Clinical Medical Center Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
Aim:
To evaluate the results of surgical treatment of patients with unilateral MRI-positive temporal forms of drug-resistant epilepsy.
Material And Methods:
A prospective analysis of 50 patients with unilateral MRI-positive temporal forms of drug-resistant epilepsy, who had undergone resective surgery in the Scientific Research Institute of Emergency Medicine of N.V. Sklifosovsky (Moscow) and in University Clinic of Moscow State University of Medicine and Dentistry between 01.01.14 and 12.12.17, has been performed. MRI-positive temporal symptomatic epilepsy was identified in 79 (55%) patients. MRI results showed unilateral temporal epileptogenic lesions in 50 (67%) patients. These patients were assigned to medial frontal lobectomy.
Results:
82% patients become 'seizure free' 12 and 24 months after surgical treatment. In other cases, seizures become less frequent and severe.
Conclusion:
The results confirm the efficacy and safety of surgical treatment of drug-resistant MRI-positive temporal forms of epilepsy.
