Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.7K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.7K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

125
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
125
Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.1K
Liver Physiology01:30

Liver Physiology

3.4K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.4K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

613
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
613
Liver Histology01:27

Liver Histology

3.9K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The metabolic vulnerability index predicts outcomes in patients with metabolic dysfunction associated steatotic liver disease.

Nature communications·2026
Same author

ABO Incompatible Deceased Donor Liver Transplants in Infants (Age < 1 Year): A Single-Center Experience.

Pediatric transplantation·2026
Same author

Diet-Dependent Cognitive Benefits of Exogenous Ketone Body Precursor, (R,S)-1,3,-Butanediol, in a Mouse Model of Tauopathy.

bioRxiv : the preprint server for biology·2026
Same author

Hepatology e-consult responses generated by artificial intelligence demonstrate accuracy but require human oversight.

Hepatology communications·2026
Same author

Endoscopic ultrasound-guided portal pressure gradient measurement for evaluation of kidney transplant candidates: A proof-of-concept study.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
Same author

Vitamin E dosing study (VEDS) in patients with metabolic dysfunction-associated steatotic liver disease with elevated aminotransferases: A multicenter, randomized, placebo-controlled trial.

Hepatology (Baltimore, Md.)·2026

Related Experiment Video

Updated: Dec 25, 2025

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
04:14

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

12.5K

Nonalcoholic Steatohepatitis: A Review.

Adam C Sheka1, Oyedele Adeyi2, Julie Thompson3

  • 1Department of Surgery, University of Minnesota, Minneapolis.

JAMA
|March 25, 2020
PubMed
Summary

Nonalcoholic steatohepatitis (NASH) is an underrecognized liver disease affecting millions, linked to obesity and diabetes. Early identification and lifestyle changes, including weight loss, are crucial for managing NASH and preventing severe outcomes like cirrhosis and transplant.

More Related Videos

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

7.3K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.5K

Related Experiment Videos

Last Updated: Dec 25, 2025

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
04:14

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

12.5K
A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
08:35

A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium

Published on: May 18, 2021

7.3K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.5K

Area of Science:

  • Hepatology
  • Internal Medicine
  • Public Health

Background:

  • Nonalcoholic steatohepatitis (NASH) is the inflammatory form of nonalcoholic fatty liver disease (NAFLD), often progressing to cirrhosis and liver transplant.
  • NASH affects 3-6% of the US population, with increasing prevalence linked to obesity, dyslipidemia, type 2 diabetes, and metabolic syndrome.
  • Despite its clinical significance, NASH remains underrecognized, with liver biopsy being the sole diagnostic standard.

Purpose of the Study:

  • To highlight the prevalence and clinical significance of NASH.
  • To emphasize the need for early identification and targeted management strategies for NASH.
  • To underscore the importance of lifestyle modifications and bariatric surgery in managing NASH and associated metabolic conditions.

Main Methods:

  • Review of current epidemiological data on NASH prevalence and risk factors.
  • Analysis of diagnostic challenges and limitations, including the role of liver biopsy.
  • Examination of current treatment paradigms, focusing on lifestyle modifications and surgical interventions.

Main Results:

  • NASH impacts 3-6% of the US population, with prevalence rising.
  • Obesity, dyslipidemia, type 2 diabetes, and metabolic syndrome are key associated conditions.
  • Approximately 20% of NASH patients develop cirrhosis, and mortality rates are significantly elevated.

Conclusions:

  • Early identification and targeted treatment of NASH are essential for improving patient outcomes.
  • Intensive lifestyle modification promoting weight loss is the primary therapeutic approach.
  • Bariatric surgery may be indicated for obesity and metabolic disease management in NASH patients.