Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

428
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
428
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

449
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
449
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

453
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
453
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

281
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
281
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

65.1K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.1K
Stress Response System01:21

Stress Response System

562
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
562

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer as a window into mitochondrial biology.

Cell metabolism·2026
Same author

Cellular memory of sub-lethal stress.

Immunity·2026
Same author

What does BCL-2 do? From new molecular insights to the clinical implications.

Cell death and differentiation·2026
Same author

Secondary Necrosis Following Caspase-Activation can Occur Independently of Gasdermin E.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Large transient assemblies of Apaf1 constitute the apoptosome in cells.

Nature communications·2025
Same author

Molecular Cell Biology of Apoptosis in Health and Disease.

Advances in experimental medicine and biology·2025

Related Experiment Video

Updated: Dec 25, 2025

Restraint to Induce Stress in Mice and Rats
03:48

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

2.8K

ER Stress Leaves an Inflammatory TRAIL.

Alba Roca Portoles1, Stephen W G Tait1

  • 1Institute of Cancer Sciences, Cancer Research UK Beatson Institute, University of Glasgow, Switchback Road, Glasgow G61 1BD, UK.

Developmental Cell
|March 26, 2020
PubMed
Summary

Cell stress triggers inflammation. Sullivan et al. (2020) discovered that TRAIL receptors unexpectedly regulate endoplasmic reticulum (ER) stress-induced inflammation, revealing a new pathway in cellular defense mechanisms.

More Related Videos

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

3.8K
The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

57.8K

Related Experiment Videos

Last Updated: Dec 25, 2025

Restraint to Induce Stress in Mice and Rats
03:48

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

2.8K
Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

3.8K
The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

57.8K

Area of Science:

  • Cellular biology
  • Immunology
  • Molecular biology

Background:

  • Cellular stress is a known trigger for inflammatory responses.
  • Inflammation serves as a protective mechanism against tissue damage and infection.
  • The precise molecular pathways linking specific cellular stresses to inflammation are not fully elucidated.

Purpose of the Study:

  • To investigate the role of TRAIL receptors in the context of endoplasmic reticulum (ER) stress.
  • To uncover novel mechanisms by which ER stress influences inflammatory signaling.
  • To identify new regulators of the cellular stress response.

Main Methods:

  • Utilized cell-based assays to model ER stress.
  • Investigated the expression and function of TRAIL receptors under stress conditions.
  • Employed molecular biology techniques to analyze signaling pathways.

Main Results:

  • Demonstrated an unexpected involvement of TRAIL receptors in ER-stress-induced inflammation.
  • Identified TRAIL receptors as key mediators linking ER stress to inflammatory signaling.
  • Characterized the specific contribution of TRAIL receptors to the inflammatory cascade.

Conclusions:

  • TRAIL receptors play a critical, previously unrecognized role in ER-stress-mediated inflammation.
  • This finding expands our understanding of the interplay between cellular stress and the immune response.
  • Suggests potential therapeutic targets for inflammatory diseases linked to ER stress.