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Updated: Dec 25, 2025
09:33
Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
Published on: June 2, 2018
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A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development
David S Lorberbaum1, Lori Sussel1
1Barbara Davis Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
Developmental Cell
|March 26, 2020
Abstract:
Notch signaling is a major regulator of pancreas development, yet how it precisely controls pancreatic cell fates has remained obscure. Seymour et al. (2020) use sophisticated Notch- based genetic tools to uncover highly context- and temporally-specific roles for DLL1, JAG1, and HES1 in regulating pancreatic progenitor cell growth and specification.
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