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Ultrasound assisted rapid synthesis of mefenamic acid based indole derivatives under ligand free Cu-catalysis: Their

Rapolu Venkateshwarlu1, Shambhu Nath Singh2, Vidavalur Siddaiah3

  • 1Custom Pharmaceutical Services and Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500049, India; Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India.

Bioorganic & Medicinal Chemistry Letters
|March 27, 2020
PubMed

Keywords:
CuIndoleMefenamic acidPDE4Ultrasound

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Primary amines react with carbonyl compounds—aldehydes and ketones—to generate imines. Imines consist of a C=N double bond and are named Schiff bases after its discoverer—the German chemist Hugo Schiff. On the other hand, secondary amines react with carbonyl compounds to give enamines. In enamines, the presence of a C=C double bond adjacent to the nitrogen atom leads to the delocalization of the lone pair.
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