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Injectable Biologics: What Is the Evidence?

Eva Kubrova1, Ryan S D'Souza, Christine L Hunt

  • 1From the Department of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, Minnesota (EK, QW, WQ); Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota (EK, AJvW); Department of Anesthesiology, Division of Pain Medicine, Mayo Clinic, Rochester, Minnesota (RSD, CLH, WQ); Department of Biochemistry & Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota (AJvW); and Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China (QW).

American Journal of Physical Medicine & Rehabilitation
|March 27, 2020
PubMed

Injectable biologics have attracted considerable interest in the field of musculoskeletal medicine. Biologics encompass a broad and diverse group of human tissue-derived therapeutics. The most commonly reported biologics for use in musculoskeletal conditions include platelet-rich plasma, bone marrow aspirate concentrate, mesenchymal stem cells, microfragmented fat, stromal vascular fraction, amniotic membrane-based products, and autologous conditioned serum. The benefits of biologics in tissue healing and regeneration are thought to be derived from their trophic, paracrine, and immunomodulatory functions. The purpose of this review is to define commonly used injectable biologics and to appraise current evidence on its efficacy in the treatment of musculoskeletal disease.

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