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Adequacy of Parenteral Nutrition in Preterm Infants According to Current Recommendations: A Study in A Spanish

Ana María Sánchez-García1, Ana Zaragoza-Martí2, Ana Cristina Murcia-López1

  • 1Department of Pharmacy Services, University General Hospital of Elche, 03203 Elche, Spain.

International Journal of Environmental Research and Public Health
|March 27, 2020
PubMed

Insights

Parenteral nutrition practices in preterm infants were evaluated. Lower gestational age and birth weight correlated with longer parenteral nutrition duration, highlighting the need for robust clinical protocols.

Area of Science:

  • Neonatology
  • Pediatric Nutrition
  • Clinical Practice Evaluation

Background:

  • Ensuring adequate nutritional intake is crucial for fetal growth in preterm infants.
  • Parenteral nutrition (PN) is essential for meeting nutritional needs in this population.
  • Clinical practice for PN prescription in preterm infants requires evaluation.

Purpose of the Study:

  • To evaluate clinical practice regarding parenteral nutrition prescription in a tertiary hospital's neonatology unit.
  • To assess compliance with hospital protocols and international guidelines (ASPEN, ESPEN, SENPE).
  • To analyze factors influencing the duration of parenteral nutrition.

Main Methods:

  • Retrospective observational study of 155 preterm infants receiving PN between January 2015 and December 2017.
  • Evaluation of adherence to hospital PN protocol and guidelines from ASPEN, ESPEN, and SENPE.
  • Analysis of macronutrient intake and PN duration based on gestational age and birth weight.

Main Results:

  • High compliance (95.5%-100%) with the hospital protocol, except for trace element initiation (64.9%).
  • Guideline compliance ranged from 82.1% to 100%, with low adherence (8.3%) to initial carbohydrate recommendations (ASPEN, ESPEN).
  • Lower gestational age and birth weight significantly correlated with longer PN duration (p < 0.001).

Conclusions:

  • Lower gestational age and birth weight are associated with extended parenteral nutrition requirements.
  • The study underscores the critical importance of developing and evaluating clinical practice protocols for PN in preterm infants.
  • Optimizing PN protocols can improve nutritional support and outcomes for vulnerable preterm neonates.
Abstract

Keywords:
parenteral nutritionpreterm newbornprotocols

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