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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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alpha-Oligodeoxynucleotide stability in serum, subcellular extracts and culture media

T A Bacon1, F Morvan, B Rayner

  • 1Department of Chemistry, University of South Florida, Tampa 33620.

Journal of Biochemical and Biophysical Methods
|August 1, 1988
PubMed

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...