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Related Experiment Video

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Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography.

Nauman Hashmani1, Maria Hashmani1, Noureen Asghar1

  • 1Department of Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, Pakistan.

Clinical Ophthalmology (Auckland, N.Z.)
|March 27, 2020
PubMed
Summary

Corneal stromal thickness mapping using SD-OCT is highly reproducible. Peripheral cornea is thicker than central, and stromal thickness decreases with age, but not with gender or axial length.

Keywords:
AS-OCTOCTcorneacorneal stromatomographytopography

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering

Background:

  • Corneal stromal thickness is a key parameter in ophthalmic assessments.
  • Understanding its variations is crucial for diagnosing and managing eye conditions.

Purpose of the Study:

  • To assess the reproducibility of corneal stromal thickness profiles obtained via SD-OCT.
  • To correlate zonal corneal stromal thicknesses with patient age, gender, and axial length.

Main Methods:

  • 227 normal eyes from 227 patients (refractive error range: -6D to +5D) were analyzed.
  • Exclusion criteria included high intraocular pressure, cataracts, and prior ophthalmic surgery.
  • Reproducibility was assessed in 50 participants using repeated scans by two operators.

Main Results:

  • Corneal stromal thickness was significantly greater in the periphery compared to the center (p<0.001).
  • A negative correlation was observed between stromal thickness and age across most sectors.
  • No significant correlations were found between stromal thickness and axial length or gender.

Conclusions:

  • SD-OCT provides highly reproducible corneal stromal thickness measurements.
  • Corneal stromal thickness exhibits a consistent pattern of being thicker peripherally and decreasing with age.
  • Gender and axial length do not appear to significantly influence corneal stromal thickness.