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Physicians' Attitudes and Ethical Obligations to Pharmacogenetic Testing
Suhaib Muflih1, Belal A Al-Husein1, Reema Karasneh2
1Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Journal of Multidisciplinary Healthcare
|March 27, 2020
Summary
Physicians support pharmacogenetic (PGt) testing but emphasize ethical considerations like patient privacy and informed consent. Addressing these challenges is crucial for PGt test implementation in clinical practice.
Area of Science:
- Medical Genetics
- Bioethics
- Clinical Pharmacology
Background:
- Pharmacogenetic (PGt) testing is increasingly used to personalize drug therapy.
- Ethical challenges associated with PGt testing remain largely unexplored.
- Physician perspectives are vital for understanding these ethical issues.
Purpose of the Study:
- To investigate physicians' views on ethical issues in PGt testing.
- To explore concerns regarding ancillary genetic information, consent, and confidentiality.
- To assess physician attitudes towards the clinical utility and implementation of PGt.
Main Methods:
- A cross-sectional study surveyed practicing physicians at King Abdulaziz University Hospital (KAUH).
- Questionnaires assessed ethical considerations, including ancillary findings, consent, and privacy.
- Physician willingness to recommend PGt testing for different age groups was evaluated.
Main Results:
- A majority of physicians were willing to recommend PGt testing for both adult (49%) and pediatric (65%) patients.
- Physicians strongly supported patient confidentiality (78.8%) and the need for informed consent (verbal and written).
- Concerns were raised about ancillary genetic information and potential future risks, with specific conditions cited for disclosure.
Conclusions:
- Ethical challenges in PGt testing, if unaddressed, may hinder its routine clinical adoption.
- Establishing clear ethical standards is essential to support physicians and facilitate PGt implementation.
- Physician buy-in and ethical guidelines are critical for the successful integration of PGt into healthcare.
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