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Assessing bladder hyper-permeability biomarkers in vivo using molecularly-targeted MRI

Rheal A Towner1,2, Nataliya Smith1, Debra Saunders1

  • 1Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation Oklahoma, OK, USA.

American Journal of Nuclear Medicine and Molecular Imaging
|March 27, 2020
PubMed
Summary

Molecularly-targeted MRI (mt-MRI) successfully visualized bladder permeability changes in a rat model of interstitial cystitis/bladder pain syndrome (IC/BPS). This imaging technique detected key molecular alterations, offering potential for improved diagnostics and therapies for IC/BPS.

Keywords:
Claudin-2decorinin vivointerstitial cystitis (IC)intravesicalmolecularly-targeted magnetic resonance imaging (mt-MRI)protamine sulfate (PS)ratsvascular endothelial growth factor receptor 1 (VEGF-R1)

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