Total knee arthroplasty in hemophilia A

Area of Science:

• Orthopedics
• Hematology
• Genetics

Background:

• Hemophilia A involves clotting factor VIII deficiency, impacting joint health.
• Recurrent hemarthrosis leads to arthropathy, often seen in young adults.
• Total joint arthroplasty is increasingly considered for hemophilic arthropathy.

Observation:

• A patient with hemophilia A and severe knee osteoarthritis underwent primary total knee arthroplasty.
• This case presents unique clinical challenges specific to hemophilia management.

Findings:

• Successful primary total knee arthroplasty in a hemophilia A patient.
• Management involved maintaining optimal factor VIII levels via infusions.
• Prevention of venous thromboembolic events was a key consideration.

Implications:

• Total knee arthroplasty is a viable treatment for severe knee osteoarthritis in hemophilia A patients.
• Careful perioperative management, including factor replacement and VTE prophylaxis, is crucial.
• This case expands understanding of surgical interventions for hemophilic arthropathy.