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Updated: Aug 8, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
The expression in Staphylococcus aureus of cloned DNA encoding methicillin resistance
B Inglis1, P R Matthews, P R Stewart
1Department of Biochemistry, Faculty of Science, Australian National University, Canberra.
Abstract:
A 4 kb fragment of chromosomal DNA was cloned from a clinical strain of methicillin-resistant Staphylococcus aureus. It comprises part of a section of the chromosome that was lost when the strain was cured of resistance to methicillin and to other antimicrobial agents. The fragment mediates an increased level of methicillin resistance when inserted into a shuttle vector and transformed back into the sensitive strain generated when the original DNA was deleted.
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